PD-1 and LAG-3 were optimal combination of immune checkpoints for predicting poor clinical outcomes of patients with ovarian cancer
Elevated IC expression correlated with poor OS in OC patients. Specifically, PD-1/LAG-3 co-expression emerged as the optimal prognostic biomarker pair, representing a promising therapeutic target for dual checkpoint blockade strategies in OC.
Authors
- Ruoyao Zou
- Cunte Chen (ORCID: https://orcid.org/0000-0003-3733-9174)
- Yingwen Cui
- Yong Du (ORCID: https://orcid.org/0000-0001-6386-0524)
- Fengjie Sun
- Peipei Wang
- Yifan Wu (ORCID: https://orcid.org/0009-0000-2032-6719)
- Yaoxiang Yang
Institutions
- Renji Hospital (CN)
- Guangzhou Women and Children Medical Center (CN)
- Guangzhou First People's Hospital (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-08-14
- DOI
- https://doi.org/10.3389/fimmu.2025.1656242
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00