Role of miR-144-5p in modulating lipid metabolism and potentially alleviating obesity via the PGC-1α/AMPK pathway
These findings suggest that miR-144-5p exerts anti-obesity effects by enhancing fatty acid oxidation, likely through modulation of the PGC-1α/AMPK signaling pathway. This study provides new insights into potential miRNA-based therapeutic strategies for obesity and related metabolic disorders.
Authors
- Xin Wen (ORCID: https://orcid.org/0000-0003-1660-0759)
- Wa Gao (ORCID: https://orcid.org/0000-0003-0720-6995)
- Ziyi Li (ORCID: https://orcid.org/0009-0004-6181-0223)
- Siriguleng Yu (ORCID: https://orcid.org/0009-0002-3816-4724)
- Zhijun Guo (ORCID: https://orcid.org/0009-0004-9821-4089)
- Chaoqun Liu (ORCID: https://orcid.org/0000-0001-8322-3290)
- Ying Xiu (ORCID: https://orcid.org/0000-0002-6893-6775)
- Yaru Niu
- Hongqiang Yao
- LV Hong
- Junjian Jin
- Wen Yu (ORCID: https://orcid.org/0000-0002-6534-6171)
Institutions
- Inner Mongolia Agricultural University (CN)
- Inner Mongolia Academy of Agricultural & Animal Husbandry Sciences (CN)
- Ministry of Agriculture (ID)
- Inner Mongolia Comprehensive Disease Prevention and Control Center (CN)
Publication Details
- Journal
- Frontiers in Veterinary Science
- Published
- 2025-08-14
- DOI
- https://doi.org/10.3389/fvets.2025.1477593
- Primary Topic
- Adipokines, Inflammation, and Metabolic Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China