Palladium-Catalyzed C–H Arylation of Quinoidal Scaffolds Through Homogeneous and Heterogeneous Pathways: Advancing Toward Trypanocidal Prototypes
A Pd-mediated C-H activation methodology was developed for the direct arylation of quinoidal skeletons, both by means of homogeneous catalysis and heterogeneous catalysis using metal-decorated carbon nanotubes, enabling the direct functionalization of quinones in moderate to excellent yields. The derivatives obtained were tested against trypomastigote forms of <i>Trypanosoma cruzi</i>, showing promising biological activity.
Authors
- Rubem F. S. Menna‐Barreto (ORCID: https://orcid.org/0000-0002-1352-0641)
- Maria H. Araújo (ORCID: https://orcid.org/0000-0002-2609-0281)
- Mateus P. Nunes (ORCID: https://orcid.org/0000-0003-4796-3448)
- Renata G. Almeida (ORCID: https://orcid.org/0000-0003-2896-0487)
- Joël Armel Tchuiteng Kouatchou (ORCID: https://orcid.org/0000-0001-7287-440X)
- Guilherme A. M. Jardim (ORCID: https://orcid.org/0000-0002-9882-3085)
- Eric Doris (ORCID: https://orcid.org/0000-0003-1318-602X)
- Eufrânio N. da Silva Júnior (ORCID: https://orcid.org/0000-0003-1281-5453)
- Edmond Gravel (ORCID: https://orcid.org/0000-0001-6077-1016)
- Eduardo F. S. Guimarães
- José M. C. Tavares
- Victor F. S. Ramos
Institutions
- Universidade Federal de Minas Gerais (BR)
- Commissariat à l'Énergie Atomique et aux Énergies Alternatives (FR)
- Université Paris-Saclay (FR)
- International Olive Council (ES)
- Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement (FR)
- Technologies pour la Santé (FR)
- Instituto de Investigaciones en Ciencias de la Salud (AR)
- CEA Paris-Saclay (FR)
- Sociedade Brasileira de Biologia Celular (BR)
- Fundação Oswaldo Cruz (BR)
Publication Details
- Journal
- ACS Omega
- Published
- 2025-08-14
- DOI
- https://doi.org/10.1021/acsomega.5c05006
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.00