Construction and immunohistochemical validation of a necroptosis-related prognostic signature in bladder cancer and its association with tumor immune infiltration
Our study delineates a novel five-gene NRG signature with robust prognostic value in BLCA. These gene determinants appear to critically influence both tumor progression and immune microenvironment, thereby representing promising candidates for therapeutic targeting and future mechanistic exploration in bladder cancer biology.
Authors
- Kai Sun (ORCID: https://orcid.org/0000-0001-9619-9007)
- Tao Wang (ORCID: https://orcid.org/0000-0001-6402-5571)
- Fei Ding (ORCID: https://orcid.org/0000-0003-3268-2029)
Institutions
- Ganzhou People's Hospital (CN)
- Lanzhou University Second Hospital (CN)
- Lanzhou University (CN)
Publication Details
- Journal
- Frontiers in Genetics
- Published
- 2025-08-14
- DOI
- https://doi.org/10.3389/fgene.2025.1527907
- Primary Topic
- Bladder and Urothelial Cancer Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00