Interferon gamma applied ex vivo restores function to neutrophils from critically ill patients
In critically ill patients with known acquired neutrophil dysfunction, ex vivo application of IFN-γ consistently improved a range of neutrophil effector functions.
Authors
- A. John Simpson (ORCID: https://orcid.org/0000-0003-4731-7294)
- Stephen E. Wright (ORCID: https://orcid.org/0000-0002-7011-0606)
- Kristen Davies (ORCID: https://orcid.org/0000-0003-2246-9048)
- Anthony Rostron (ORCID: https://orcid.org/0000-0002-9336-1723)
- Kathryn Musgrave (ORCID: https://orcid.org/0000-0003-4984-475X)
- I Clement' (ORCID: https://orcid.org/0000-0001-9854-6674)
- Daniel I. Brooks (ORCID: https://orcid.org/0000-0003-1164-2773)
- Marie‐Hélène Ruchaud‐Sparagano
- Richard Davidson (ORCID: https://orcid.org/0000-0001-7118-4941)
- Wezi Sendama (ORCID: https://orcid.org/0000-0002-4686-3368)
- Chung Mun Alice Lin (ORCID: https://orcid.org/0000-0002-3075-8344)
- Polina Yarova (ORCID: https://orcid.org/0000-0002-7534-7995)
- Wendy Funston (ORCID: https://orcid.org/0000-0002-6521-1103)
- Jason Powell (ORCID: https://orcid.org/0000-0002-1199-8406)
- Jonathan Scott (ORCID: https://orcid.org/0000-0003-3102-4294)
- Thomas P Hellyer (ORCID: https://orcid.org/0000-0001-5346-7411)
- Fiona Dewar
- John A. Thompson
- Cameron J. Lake
- Alistair Roy
Institutions
- Newcastle upon Tyne Hospitals NHS Foundation Trust (GB)
- Sunderland Royal Hospital (GB)
- Great North Children's Hospital (GB)
- Newcastle University (GB)
Publication Details
- Journal
- Thorax
- Published
- 2025-08-28
- DOI
- https://doi.org/10.1136/thorax-2025-223280
- Primary Topic
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00