Comprehensive proteomic characterization of pulmonary arterial hypertension in Chinese people
Dysregulated pathways such as autophagy, apoptosis, and HIF-1 signaling, along with altered genes or proteins, contribute to PAH by inducing pulmonary vascular remodeling and chronic vasoconstriction. These findings may facilitate the discovery of novel therapeutic targets and effective treatment strategies for PAH.
Authors
- Zhiping Wang (ORCID: https://orcid.org/0000-0003-4985-9003)
- Siqi Zhou (ORCID: https://orcid.org/0000-0002-0668-340X)
- Jie Zu
- Xiaomei Xu
- Tianya Liu (ORCID: https://orcid.org/0000-0003-3995-5982)
- Fang Gao (ORCID: https://orcid.org/0000-0002-2645-3396)
- Rui Wang (ORCID: https://orcid.org/0009-0001-9020-4984)
Institutions
- Xuzhou Medical College (CN)
- Affiliated Hospital of Xuzhou Medical College (CN)
- Nanjing Drum Tower Hospital (CN)
Publication Details
- Journal
- Frontiers in Molecular Biosciences
- Published
- 2025-08-14
- DOI
- https://doi.org/10.3389/fmolb.2025.1652083
- Primary Topic
- Pulmonary Hypertension Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00