Kangshujiangu granules improve NAFLD via cross-organ autophagy activation shared with osteoporosis
OP exhibited a negative correlation with lipid metabolism indexes of NAFLD. Bilateral ovariectomy (OVX) simultaneously induced OP and NAFLD, while KSJG granules ameliorated lipid dysregulation via autophagy modulation. KSJG granules enhanced autophagy activation through the AMPK/ULK1 (Ser555) pathway, thereby alleviating NAFLD-associated lipid metabolic disturbances.
Authors
- Che Wang (ORCID: https://orcid.org/0000-0001-5775-2236)
- Qiling Liu (ORCID: https://orcid.org/0000-0002-3479-5601)
- Li Song (ORCID: https://orcid.org/0000-0003-1415-584X)
- Na Wang (ORCID: https://orcid.org/0000-0001-5969-6733)
- Yue Peng (ORCID: https://orcid.org/0000-0002-8541-0265)
- Zhengsen Long (ORCID: https://orcid.org/0000-0003-3784-3741)
- Larry Lai Wei
- Chuandao Shi
Institutions
- Chinese Academy of Sciences (CN)
- Guangzhou Institutes of Biomedicine and Health (CN)
- Shaanxi University of Chinese Medicine (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-08-14
- DOI
- https://doi.org/10.3389/fphar.2025.1633813
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Shaanxi University of Chinese Medicine