Combinatorial mutagenesis and fermentation optimization biotechnologies synergistically enhance monacolin K content in functional red yeast rice
This work successfully demonstrates a synergistic approach combining advanced combinatorial mutagenesis with precise bioprocess optimization to substantially improve MK yield. The overproducing <i>M. purpureus</i> CSUFT-1 and the optimized SSF protocol provide both microbial resource and technical protocol for industrial-scale production of RYR with high MK.
Authors
- Jun Liu (ORCID: https://orcid.org/0000-0002-1627-0377)
- Xiang Zhou (ORCID: https://orcid.org/0000-0001-6722-5800)
- Song Zhang (ORCID: https://orcid.org/0000-0002-1263-6693)
- Qi Yang (ORCID: https://orcid.org/0000-0001-6781-770X)
- Chan Zhang (ORCID: https://orcid.org/0000-0002-3555-7920)
- Dong Lü (ORCID: https://orcid.org/0000-0003-2856-1785)
- Qing Liu (ORCID: https://orcid.org/0000-0003-1357-4866)
- Zhengyan Wu
Institutions
- Central South University of Forestry and Technology (CN)
- Central South University (CN)
- Beijing Technology and Business University (CN)
- Chinese Academy of Sciences (CN)
- Institute of Modern Physics (CN)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2025-08-14
- DOI
- https://doi.org/10.3389/fmicb.2025.1669985
- Citations
- 3
- Primary Topic
- Microbial Metabolism and Applications
- Type
- article
- Field-Weighted Citation Impact
- 3.70
Funders
- Beijing Technology and Business University