Neutrophil store-operated Ca2+ entry: A correctable biomarker of cystic fibrosis lung disease progression
Our findings highlight SOCE as a novel biomarker of CF lung disease. ELD607 can be used to reduce SOCE and subsequent degranulation in CF neutrophils. We therefore hypothesize that ELD607 may be of benefit in the management of inflammation in pwCF.
Authors
- Matthew Biggart (ORCID: https://orcid.org/0000-0002-9301-5695)
- Maria F. Sassano (ORCID: https://orcid.org/0000-0003-1243-2962)
- Charles D. Bengtson (ORCID: https://orcid.org/0000-0002-3177-3992)
- Joe A. Wrennall
- Robert Tarran (ORCID: https://orcid.org/0000-0002-8598-2642)
Institutions
- University of North Carolina at Chapel Hill (US)
- University of Kansas Medical Center (US)
Publication Details
- Journal
- Journal of Cystic Fibrosis
- Published
- 2025-08-27
- DOI
- https://doi.org/10.1016/j.jcf.2025.08.014
- Citations
- 2
- Primary Topic
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 1.59