Urinary bladder paraganglioma in pregnancy: a case report and literature review

Urinary bladder paragangliomas (UBPs) are rare tumors of chromaffin tissue originating from the sympathetic innervation of the bladder wall. It constitutes less than 0.05% of bladder tumors and 0.7% of all paragangliomas. The occurrence of UBP during pregnancy is extremely rare. Hypertensive disorders of pregnancy due to paraganglioma significantly increase the risk of adverse maternal and fetal outcomes. Herein, we report the case of UBP in a 28-year-old woman at 34 weeks' gestation. The baby was successfully delivered, and bladder tumor was excised via partial cystectomy during the same surgical procedure. In addition, we conducted a literature review of paragangliomas during pregnancy, as there are only a few case reports of such diseases and there is no consensus on standard treatment. This study aims to contribute to the enhancement of the diagnosis and treatment of UBP during pregnancy.

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Publication Details

Journal
Frontiers in Medicine
Published
2025-08-14
DOI
https://doi.org/10.3389/fmed.2025.1527778
Primary Topic
Adrenal and Paraganglionic Tumors
Type
article
Field-Weighted Citation Impact
0.00

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article

Urinary bladder paraganglioma in pregnancy: a case report and literature review

Yadong Sun, Lili Chen, Yongxiang Li, Liang Qiao
Frontiers in Medicine
Adrenal and Paraganglionic Tumors
article

Urinary bladder paraganglioma in pregnancy: a case report and literature review

Yadong Sun, Lili Chen, Yongxiang Li, Liang Qiao
article en

Abstract

Urinary bladder paragangliomas (UBPs) are rare tumors of chromaffin tissue originating from the sympathetic innervation of the bladder wall. It constitutes less than 0.05% of bladder tumors and 0.7% of all paragangliomas. The occurrence of UBP during pregnancy is extremely rare. Hypertensive disorders of pregnancy due to paraganglioma significantly increase the risk of adverse maternal and fetal outcomes. Herein, we report the case of UBP in a 28-year-old woman at 34 weeks' gestation. The baby was successfully delivered, and bladder tumor was excised via partial cystectomy during the same surgical procedure. In addition, we conducted a literature review of paragangliomas during pregnancy, as there are only a few case reports of such diseases and there is no consensus on standard treatment. This study aims to contribute to the enhancement of the diagnosis and treatment of UBP during pregnancy.

Frontiers in MedicineVol. 12
Weifang Medical University (CN), Union Hospital (HK), Wuhan Prevention and Treatment Center for Occupational Diseases (CN), Huazhong University of Science and Technology (CN)
Natural Science Foundation of Shandong Province
Openalex Percentile: Top 62%
Adrenal and Paraganglionic Tumors
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Urinary bladder paraganglioma in pregnancy: a case report and literature review — Yadong Sun, Lili Chen, et al. · Frontiers in Medicine (2025) | TGRS Research Map | TGRS