Sarsasapogenin protects hair cells from cisplatin-induced ototoxicity by attenuating apoptosis and ferroptosis via alleviating oxidative stress
This study provides compelling evidence for the otoprotective effects of sarsasapogenin, suggesting its potential as a therapeutic intervention to prevent cisplatin-induced hearing loss.
Authors
- Yuqing Chen (ORCID: https://orcid.org/0000-0001-9742-2661)
- Yanchun Lin (ORCID: https://orcid.org/0000-0003-1907-9495)
- Xiaobo Wu (ORCID: https://orcid.org/0000-0001-5347-948X)
- Chenyu Chen (ORCID: https://orcid.org/0000-0003-3811-396X)
- Xiaoyang Luo
- Zhifeng Chen (ORCID: https://orcid.org/0000-0003-3662-0992)
- Tingting Lin (ORCID: https://orcid.org/0000-0003-1634-0483)
- Ting Xie (ORCID: https://orcid.org/0009-0002-6832-0978)
- Chang Lin
- Chaojun Zeng (ORCID: https://orcid.org/0000-0002-5978-0430)
Institutions
- University of Science and Technology of China (CN)
- Fujian Medical University (CN)
- Eye & ENT Hospital of Fudan University (CN)
- First Affiliated Hospital of Fujian Medical University (CN)
- Putian University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-08-14
- DOI
- https://doi.org/10.3389/fphar.2025.1641174
- Citations
- 1
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 0.94