Inflammatory markers as potential mediators on the negative association between training load and bone mineral density in adolescent competitive swimmers: ABCD-growth study
The swimming and non-sports groups did not show differences in bone, inflammatory, or immunological markers. In contrast, swimmers had higher concentrations of IGF-1, calcium, and 25-hydroxy vitamin D. Although the training load was negatively associated with aBMD, inflammatory markers (IL-6 and CRP) did not mediate this association. Reinforcing the hypothesis that swimmers have lower aBMD due to the hypogravitational environment.
Authors
- Ricardo Ribeiro Agostinete (ORCID: https://orcid.org/0000-0001-8420-7225)
- Renata Moraes Bielemann (ORCID: https://orcid.org/0000-0003-0202-3735)
- Pedro Henrique Narciso (ORCID: https://orcid.org/0000-0002-3829-7466)
- Dimitris Vlachopoulos (ORCID: https://orcid.org/0000-0003-1556-715X)
- Bruna Camilo Turi-Lynch (ORCID: https://orcid.org/0000-0002-1314-6258)
- Luís Alberto Gobbo (ORCID: https://orcid.org/0000-0003-4700-0000)
- Rômulo Araújo Fernandes (ORCID: https://orcid.org/0000-0003-1576-8090)
- Manuel João Coelho-e-Silva (ORCID: https://orcid.org/0000-0003-4512-7331)
Institutions
- Universidade Federal de Pelotas (BR)
- Lander University (US)
- University of Exeter (GB)
- Hospital Regional de Presidente Prudente (BR)
- University of Coimbra (PT)
- Universidade Estadual Paulista (Unesp) (BR)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2025-08-14
- DOI
- https://doi.org/10.3389/fendo.2025.1602551
- Primary Topic
- Muscle metabolism and nutrition
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Fundação de Amparo à Pesquisa do Estado de São Paulo
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Universidade Estadual Paulista