Glioblastoma tumor microtubes and brain fatty acid-binding protein: Path to directional infiltration
We found that the FABP7-PKC-pGAP43 axis is key to GBM TM formation, with TMs serving as networks for efficient long-distance cell migration. Our results indicate that TM formation can be mitigated by FABP7 inhibition with the potential of improving clinical outcomes in GBM patients.
Authors
- Roseline Godbout (ORCID: https://orcid.org/0000-0002-4779-9265)
- Wonshik Choi (ORCID: https://orcid.org/0000-0002-9445-7081)
- Frank K.H. van Landeghem (ORCID: https://orcid.org/0000-0002-9404-7031)
- Pureunsol Jeon
- Amirali B. Bukhari (ORCID: https://orcid.org/0000-0003-0543-1339)
- Ing Swie Goping (ORCID: https://orcid.org/0000-0001-6355-827X)
- Monica Larocque (ORCID: https://orcid.org/0000-0001-8109-9222)
- Caitlin Mak
- Karolyn Au (ORCID: https://orcid.org/0000-0001-5536-2971)
- Rong‐Zong Liu (ORCID: https://orcid.org/0000-0001-8625-3188)
- John Maringa Githaka (ORCID: https://orcid.org/0000-0003-1974-0415)
- Darryl Glubrecht
- Daniel E. McGinn (ORCID: https://orcid.org/0009-0008-6006-1426)
- Mansi Garg
- S.C. Peyton
- Xuejun Sun (ORCID: https://orcid.org/0000-0003-2387-5531)
- Xia Xu (ORCID: https://orcid.org/0000-0003-4718-1526)
- Lubna Yasmin
Institutions
- College of the Holy Cross (US)
- University of Alberta (CA)
- Alberta Cancer Foundation (CA)
Publication Details
- Journal
- Neuro-Oncology
- Published
- 2025-08-25
- DOI
- https://doi.org/10.1093/neuonc/noaf200
- Primary Topic
- Peroxisome Proliferator-Activated Receptors
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Canadian Institutes of Health Research