Effects of high-intensity interval training on physical and cognitive function in middle-aged male mice

We note that at 17 months of age, mice did not exhibit any evidence of cognitive deterioration in either group over the training period, thus potentially explaining the lack of an exercise effect. We found that HIIT had less influence on both physical and cognitive function than expected, which may be because function in this age group remains relatively stable. Future work will investigate the adult cognitive response to HIIT in older adults, at ages where there is well- documented cognitive decline.