Three weeks of environmental enrichment enhance hepatic-muscular oxidative balance and decrease interleukin-6 levels in juvenile female C57BL/6 mice

EE significantly reduced body weight and malondialdehyde levels in the liver, soleus, and EDL muscles. Additionally, carbonyl levels decreased in the liver and soleus. Acute EE exposure enhanced enzymatic antioxidant activity (SOD, CAT, and GST) across all tissues, except for catalase activity in the EDL, which showed no significant difference between groups. Non-enzymatic defenses were improved, with reduced oxidized glutathione (GSSG) levels in the liver and soleus. Furthermore, EE increased the REDOX status in the liver and EDL. Sulfhydryl levels increased only in the liver. Finally, serum cytokine analysis revealed a significant reduction only in IL-6 levels. These findings suggest that three weeks of EE can modulate hepatic and muscular oxidative balance, as well as serum IL-6 levels, in juvenile female mice.

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Publication Details

Journal
Frontiers in Physiology
Published
2025-08-14
DOI
https://doi.org/10.3389/fphys.2025.1626477
Primary Topic
Adipose Tissue and Metabolism
Type
article
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article

Three weeks of environmental enrichment enhance hepatic-muscular oxidative balance and decrease interleukin-6 levels in juvenile female C57BL/6 mice

Débora Eduarda da Silva Fidelis, Crislaine da Silva, Matheus Santos de Sousa Fernandes, Cláudia Nóbrega et al.
Frontiers in Physiology
Adipose Tissue and Metabolism
article

Three weeks of environmental enrichment enhance hepatic-muscular oxidative balance and decrease interleukin-6 levels in juvenile female C57BL/6 mice

Débora Eduarda da Silva Fidelis, Crislaine da Silva, Matheus Santos de Sousa Fernandes, Cláudia Nóbrega, Fatma Hilal Yağın, Mariana Pinheiro Fernandes, Reem Mohammed Alwhaibi, Yalın Aygün, Valdênia Maria Oliveira de Souza, Fabrício Oliveira Souto, Cláudia Jacques Lagranha, Allifer Rosendo Perreira, Tiago Lacerda Ramos
article en

Abstract

EE significantly reduced body weight and malondialdehyde levels in the liver, soleus, and EDL muscles. Additionally, carbonyl levels decreased in the liver and soleus. Acute EE exposure enhanced enzymatic antioxidant activity (SOD, CAT, and GST) across all tissues, except for catalase activity in the EDL, which showed no significant difference between groups. Non-enzymatic defenses were improved, with reduced oxidized glutathione (GSSG) levels in the liver and soleus. Furthermore, EE increased the REDOX status in the liver and EDL. Sulfhydryl levels increased only in the liver. Finally, serum cytokine analysis revealed a significant reduction only in IL-6 levels. These findings suggest that three weeks of EE can modulate hepatic and muscular oxidative balance, as well as serum IL-6 levels, in juvenile female mice.

Frontiers in PhysiologyVol. 16
Princess Nourah bint Abdulrahman University (SA), Inonu University (TR), Universidade Federal de Pernambuco (BR), Universidade Federal do Espírito Santo (BR), Turgut Özal University (TR)
Openalex Percentile: Top 71%
Adipose Tissue and Metabolism
DOIOpen Access PDFOpenAlex
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