Daphnetin alleviates renal inflammation, oxidative stress, and apoptosis in septic rats via the JAK2/STAT3 signaling pathway.
experiments showed that DAP or AG490 (a JAK2 inhibitor) alleviated LPS-induced apoptosis, inflammation, and oxidative stress. In conclusion, DAP attenuates sepsis-induced AKI by reducing inflammation, oxidative stress, and apoptosis via the inactivation of the JAK2/STAT3 pathway.
Authors
- Qingye Li (ORCID: https://orcid.org/0009-0009-4416-7703)
- Yingling Wang
- Zhuo Zhang (ORCID: https://orcid.org/0000-0002-0013-432X)
- Pan Hu (ORCID: https://orcid.org/0000-0002-7149-1527)
- Runchen Yao (ORCID: https://orcid.org/0009-0007-8759-7039)
Institutions
- Hubei Provincial Hospital of Traditional Chinese Medicine (CN)
- Shanghai Traditional Chinese Medicine Hospital (CN)
Publication Details
- Journal
- PubMed
- Published
- 2026-04-01
- DOI
- https://doi.org/10.14670/hh-18-978
- Primary Topic
- Pharmacological Effects of Natural Compounds
- Type
- article
- Field-Weighted Citation Impact
- 0.00