Temporal Changes in Biomarkers, Functional Status, and Quality of Life Prior to Adverse Clinical Outcomes in Heart Failure With Mildly Reduced or Preserved Ejection Fraction
In a large HFmrEF/HFpEF trial population, clinically meaningful changes in readily available biomarkers, functional status, and patient-reported health status were observed in the months leading up to a clinical event. Monitoring these parameters may help identify patients at high risk for near-term adverse clinical events. (Finerenone Trial to Investigate the Efficacy and Safety Superior to Placebo in Patients With Heart Failure [FINEARTS-HF]; NCT04435626).
Authors
- Bertram Pitt
- Brian Lee Claggett (ORCID: https://orcid.org/0000-0002-4215-9218)
- Mario Berger (ORCID: https://orcid.org/0000-0002-9048-3928)
- Pardeep S. Jhund (ORCID: https://orcid.org/0000-0003-4306-5317)
- John J.V. McMurray (ORCID: https://orcid.org/0000-0002-6317-3975)
- Laura Goea (ORCID: https://orcid.org/0000-0003-0473-2885)
- Scott David Solomon (ORCID: https://orcid.org/0000-0003-3698-9597)
- Muthiah Vaduganathan (ORCID: https://orcid.org/0000-0003-0885-1953)
- Adriaan A. Voors (ORCID: https://orcid.org/0000-0002-5417-4415)
- Andrea Scalise (ORCID: https://orcid.org/0000-0002-9367-5773)
- Henri Lu (ORCID: https://orcid.org/0000-0002-9074-6505)
- Michele Senni
- Sanjiv J. Shah (ORCID: https://orcid.org/0000-0002-5655-8201)
- Carolyn Lam
- Katharina Mueller
- Akshay S. Desai
- Markus F. Scheerer
- Faiez Zannad
Institutions
- Northwestern University (US)
- Brigham and Women's Hospital (US)
- University Medical Center Groningen (NL)
- Harvard University (US)
- Inserm (FR)
- National University of Singapore (SG)
- University of Michigan (US)
- British Heart Foundation (GB)
- Ospedale Papa Giovanni XXIII (IT)
- National University Heart Centre Singapore (SG)
- National Heart Centre Singapore (SG)
- Bayer (Germany) (DE)
- University of Glasgow (GB)
- Université de Lorraine (FR)
- University of Lausanne (CH)
Publication Details
- Journal
- JACC Heart Failure
- Published
- 2025-08-25
- DOI
- https://doi.org/10.1016/j.jchf.2025.102590
- Citations
- 2
- Primary Topic
- Heart Failure Treatment and Management
- Type
- article
- Field-Weighted Citation Impact
- 2.78