Neurofilament light chain concentration mediates the association between regional cortical thickness and Parkinson’s disease with excessive daytime sleepiness
Plasma NfL levels mediate the association between cortical thinning in the left SMG and EDS severity in PD-EDS, suggesting a link between neurodegenerative processes underlying axonal injury and cortical atrophy in key regions associated with EDS in PD. Our findings suggest that combining neuroimaging markers with plasma NfL levels may provide valuable insights into the mechanisms driving EDS progression in PD.
Authors
- Jianzhun Chen
- Baiyuan Yang
- Xinglong Yang (ORCID: https://orcid.org/0000-0001-5801-5211)
- Chenxi Liu (ORCID: https://orcid.org/0000-0001-5888-4097)
- Chunyu Liang (ORCID: https://orcid.org/0000-0002-2007-9583)
- Jieyu Chen (ORCID: https://orcid.org/0000-0002-6254-4324)
- Guoliang Jiang (ORCID: https://orcid.org/0009-0008-0844-1421)
- Yongyun Zhu
Institutions
- Kunming Medical University (CN)
- First Affiliated Hospital of Kunming Medical University (CN)
- Seventh People's Hospital of Shanghai (CN)
Publication Details
- Journal
- Frontiers in Aging Neuroscience
- Published
- 2025-08-14
- DOI
- https://doi.org/10.3389/fnagi.2025.1645290
- Citations
- 1
- Primary Topic
- Sleep and Wakefulness Research
- Type
- article
- Field-Weighted Citation Impact
- 1.43
Funders
- Kunming Medical University