Hippocampal dysmetabolism contributes to cognitive loss in autoimmune encephalitis and focal temporal epilepsy
Although AE and TLE patients report similar cognitive issues, their hippocampal metabolic signatures differ. The disease-specific changes in the measures of hippocampal inflammation and neuronal integrity can inform trajectories for cognitive recovery and be targeted therapeutically.
Authors
- Tracy Jasinski
- Olga D. Taraschenko (ORCID: https://orcid.org/0000-0003-4848-8909)
- Shelley Lee
- Kathleen N. Greenman
- Rana Zabad (ORCID: https://orcid.org/0000-0003-3170-7108)
- Lakshman Arcot Jayagopal (ORCID: https://orcid.org/0000-0003-1259-0610)
- Mariano Uberti (ORCID: https://orcid.org/0000-0002-7535-3682)
- Matthew L. White (ORCID: https://orcid.org/0000-0003-4292-2073)
- Audrina Mullane
- Hesham Ghonim
Institutions
- Nebraska Medical Center (US)
- Institute of Neuroimmunology of the Slovak Academy of Sciences (SK)
- University of Nebraska Medical Center (US)
Publication Details
- Journal
- Frontiers in Neurology
- Published
- 2025-08-14
- DOI
- https://doi.org/10.3389/fneur.2025.1597928
- Primary Topic
- Autoimmune Neurological Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00