Activation of farnesoid X receptor upregulates binding immunoglobulin protein expression and alleviates diabetic nephropathy
FXR promotes BiP expression by binding to its promoter, suppressing ERS pathways, and reducing mesangial cell proliferation and ECM synthesis. These findings highlight FXR as a potential therapeutic target for diabetic glomerulosclerosis.
Authors
- Jianying Tang
- Yang Lu (ORCID: https://orcid.org/0000-0002-1131-7324)
- Jun-Chen Li (ORCID: https://orcid.org/0000-0003-4557-0595)
- Ying Yang (ORCID: https://orcid.org/0000-0002-0087-2648)
- Young-Sook Chong (ORCID: https://orcid.org/0000-0002-9289-1060)
- Xue Li (ORCID: https://orcid.org/0000-0003-4836-7808)
- Jiao Mu (ORCID: https://orcid.org/0009-0002-4402-0241)
Institutions
- Chongqing Medical University (CN)
Publication Details
- Journal
- World Journal of Diabetes
- Published
- 2025-08-14
- DOI
- https://doi.org/10.4239/wjd.v16.i8.105228
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 0.00