Synthesis and Anti-cancer Evaluation of Novel Tetrandrine Derivatives as Potential Apoptosis Inducers through targeting AKT1
Twenty-four novel 14N-substituted tetrandrine (Tet) were synthesized and investigated for their effects on anti-proliferative activities against human cancer cell lines HepG2 and A549 by the MTT method. A structure-activity relationship (SAR) study di
Authors
- Ruiqi Fan (ORCID: https://orcid.org/0000-0002-7120-2561)
- Hongbao Hou (ORCID: https://orcid.org/0000-0001-9086-466X)
- Yi Zhang (ORCID: https://orcid.org/0000-0003-0305-3127)
- Tao Wang (ORCID: https://orcid.org/0000-0001-7740-5979)
- Qingxuan Zeng
- Yukun Lin
Institutions
- Shanxi Medical University (CN)
Publication Details
- Published
- 2025-09-03
- DOI
- https://doi.org/10.22541/au.175692124.48405537/v1
- Primary Topic
- Berberine and alkaloids research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Chinese Academy of Sciences