Cell Type–Specific Expression of Long Noncoding RNAs in Human Diabetic Kidneys Identifies TARID as a Key Regulator of Podocyte Function
This study provides a resource for kidney (cell type-specific) long noncoding (lnc)RNA expression and demonstrates the importance of lncRNAs in renal health. We identified 174 cell type-specific lncRNAs in the human kidney, with 54 showing altered expression in diabetic kidney disease. TCF21 antisense RNA inducing promoter demethylation (TARID), a podocyte-specific lncRNA upregulated in diabetic kidney disease, is crucial for actin cytoskeleton reorganization in podocytes.
Authors
- Hans J. Baelde (ORCID: https://orcid.org/0000-0002-1214-500X)
- Rudmer J. Postma
- Coen van Solingen
- Anton Jan van Zonneveld (ORCID: https://orcid.org/0000-0002-1676-7738)
- Sébastien J. Dumas (ORCID: https://orcid.org/0000-0001-9958-3485)
- Leen M. ‘t Hart (ORCID: https://orcid.org/0000-0003-4401-2938)
- Juliette A. de Klerk (ORCID: https://orcid.org/0000-0002-7018-3143)
- Loïs A.K. van der Pluijm (ORCID: https://orcid.org/0000-0002-2111-3296)
- Roel Bijkerk (ORCID: https://orcid.org/0000-0002-6438-4133)
- Roderick C. Slieker (ORCID: https://orcid.org/0000-0003-0961-9152)
- Tessa Gerrits (ORCID: https://orcid.org/0000-0002-3722-1152)
- Heein Song
- Benjamin D. Humphreys (ORCID: https://orcid.org/0000-0002-6420-8703)
- Joris I. Rotmans (ORCID: https://orcid.org/0000-0001-9682-6234)
- W. E. Parker (ORCID: https://orcid.org/0000-0003-2192-5937)
- Yoshiharu Muto (ORCID: https://orcid.org/0000-0002-0358-9442)
- Marije Koning (ORCID: https://orcid.org/0000-0001-9094-1004)
- H. Siebe Spijker (ORCID: https://orcid.org/0000-0001-6144-3858)
- Hao Wu (ORCID: https://orcid.org/0000-0002-7866-2544)
- Janneke H D Peerlings (ORCID: https://orcid.org/0000-0002-0973-1091)
- Floris Herrewijnen
Institutions
- Washington University in St. Louis (US)
- Leiden University Medical Center (NL)
- Novo Nordisk Foundation (DK)
- New York University (US)
Publication Details
- Journal
- Diabetes
- Published
- 2025-09-03
- DOI
- https://doi.org/10.2337/db25-0272
- Primary Topic
- Renal Diseases and Glomerulopathies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- American Heart Association
- European Foundation for the Study of Diabetes
- Nierstichting
- Novo Nordisk
- Novo Nordisk Fonden