Covert Transthyretin Amyloidosis Mimicking Advanced Obstructive Hypertrophic Cardiomyopathy Despite Multiple Negative 99mTc-PYP Radionuclide Scans
TTR amyloidosis can mimic hypertrophic cardiomyopathy with left ventricular outflow tract obstruction. 99m Technetium pyrophosphate scans are useful to investigate the presence of TTR amyloid, but if suspicion persists despite negative testing, it is reasonable to perform an endomyocardial biopsy.
Authors
- Daniele Massera (ORCID: https://orcid.org/0000-0002-9499-6456)
- Alex Reyentovich (ORCID: https://orcid.org/0000-0002-1687-6053)
- Maria C. Reuter (ORCID: https://orcid.org/0000-0003-4789-2600)
- Joseph J. Maleszewski (ORCID: https://orcid.org/0000-0003-3239-6460)
- Mark V. Sherrid (ORCID: https://orcid.org/0000-0003-4972-7780)
- Daniel J. Larson (ORCID: https://orcid.org/0000-0002-8267-7423)
- Jose Alvarez‐Cardona
- Fang Zhou (ORCID: https://orcid.org/0000-0002-5542-2994)
- Lawrence M. Phillips
- Woon Wu
Institutions
- Mayo Clinic (US)
- NYU Langone Health (US)
- Amyloidosis Foundation (US)
Publication Details
- Journal
- JACC Case Reports
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1016/j.jaccas.2025.104918
- Primary Topic
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- New York University
- Clinical and Translational Science Institute, New York University