A traditional Cameroonian spice, Syzygium guineense curtails leukemia tumor growth through G2-M cell cycle arrest and predicted NLRP3 inflammasome pathway
Our study has provided interesting leads that Cameroonian spice S. guineense fractions/extract exhibited anti-leukemia activity, which could be mediated by inhibiting the innate immune inflammasome pathway. The study emphasizes the importance of S. guineense plant parts that have the potential to be developed for novel targeted therapeutics for leukemia.
Authors
- Jean‐Bosco Jouda (ORCID: https://orcid.org/0000-0001-7028-238X)
- Francine Tankeu Nzufo (ORCID: https://orcid.org/0000-0002-8687-458X)
- Subrata Sen (ORCID: https://orcid.org/0000-0003-2746-2769)
- Constant Anatole Pieme (ORCID: https://orcid.org/0000-0003-1602-6494)
- Ninon G.E.R. Etsassala (ORCID: https://orcid.org/0000-0002-6531-4102)
- Jyoti Kode (ORCID: https://orcid.org/0000-0001-6907-2449)
- Nirmal Kumar Kasinathan (ORCID: https://orcid.org/0000-0002-8980-7198)
- Showkat Ahmad Mir (ORCID: https://orcid.org/0000-0002-3668-2184)
- Trupti Pradhan (ORCID: https://orcid.org/0000-0001-5491-2070)
- Rajesh Kumar Meher (ORCID: https://orcid.org/0000-0002-5762-0476)
- Madan Barkume
- Satyanshu Kumar (ORCID: https://orcid.org/0000-0003-1212-0096)
Institutions
- Sambalpur University (IN)
- Université de Yaoundé I (CM)
- University of the Free State (ZA)
- Directorate of Medicinal and Aromatic Plants Research (IN)
- Advanced Centre for Treatment, Research and Education in Cancer (IN)
- University of Ngaoundéré (CM)
- Nelson Mandela University (ZA)
Publication Details
- Journal
- Journal of Ayurveda and Integrative Medicine
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1016/j.jaim.2025.101202
- Primary Topic
- Cancer, Lipids, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Tata Memorial Centre
- Advanced Centre for Treatment, Research and Education in Cancer