Association Between Consumption of Low- and No-Calorie Artificial Sweeteners and Cognitive Decline
Consumption of LNCSs was associated with an accelerated rate of cognitive decline during 8 years of follow-up. Our findings suggest the possibility of long-term harm from LNCS consumption, particularly artificial LNCSs and sugar alcohols, on cognitive function. Study limitations include self-reported dietary data, selection bias from attrition, and residual confounding from co-occurring health behaviors.
Authors
- María del Carmen Bisi Molina (ORCID: https://orcid.org/0000-0001-8746-5860)
- Sandhi Maria Barreto (ORCID: https://orcid.org/0000-0001-7383-7811)
- Isabela M. Benseñor (ORCID: https://orcid.org/0000-0002-6723-5678)
- Luana Giatti (ORCID: https://orcid.org/0000-0001-5454-2460)
- Paulo A. Lotufo (ORCID: https://orcid.org/0000-0002-4856-8450)
- Paulo Caramelli (ORCID: https://orcid.org/0000-0002-4786-6990)
- Alessandra C. Goulart (ORCID: https://orcid.org/0000-0003-1076-5210)
- Cláudia Kimie Suemoto (ORCID: https://orcid.org/0000-0002-5942-4778)
- Natália Gomes Gonçalves (ORCID: https://orcid.org/0000-0002-5253-5483)
- Eurídice Martínez Steele (ORCID: https://orcid.org/0000-0002-2907-3153)
- Dirce Maria Lobo Marchioni (ORCID: https://orcid.org/0000-0002-6810-5779)
- Carolina Perim de Faria (ORCID: https://orcid.org/0000-0001-9165-1332)
Institutions
- Universidade Federal de Minas Gerais (BR)
- Instituto de Saúde (BR)
- Hospital Universitário da Universidade de São Paulo (BR)
- Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (BR)
- Fundação Faculdade de Medicina (BR)
- Universidade Federal do Espírito Santo (BR)
Publication Details
- Journal
- Neurology
- Published
- 2025-09-03
- DOI
- https://doi.org/10.1212/wnl.0000000000214023
- Citations
- 6
- Primary Topic
- Biochemical Analysis and Sensing Techniques
- Type
- article
- Field-Weighted Citation Impact
- 6.72