One Dose versus Three Doses of Benzathine Penicillin G in Early Syphilis
Treatment with one dose of 2.4 million units of benzathine penicillin G was noninferior to treatment with three doses with regard to serologic response 6 months after treatment. (Funded by the National Institute of Allergy and Infectious Diseases; ClinicalTrials.gov number, NCT03637660.).
Authors
- Arlene C. Seña (ORCID: https://orcid.org/0000-0002-1206-2175)
- Candice J. McNeil (ORCID: https://orcid.org/0000-0003-0566-9515)
- Matthew M. Hamill (ORCID: https://orcid.org/0000-0002-1277-819X)
- Harold C. Wiesenfeld (ORCID: https://orcid.org/0000-0002-6094-1238)
- Lori M. Newman (ORCID: https://orcid.org/0000-0001-5464-5208)
- Stephanie N. Taylor (ORCID: https://orcid.org/0000-0002-9144-4277)
- Teresa A. Batteiger (ORCID: https://orcid.org/0000-0002-5097-1425)
- Edward W. Hook (ORCID: https://orcid.org/0000-0002-8515-2884)
- Julia C. Dombrowski (ORCID: https://orcid.org/0000-0003-1907-9428)
- Kimberly Workowski (ORCID: https://orcid.org/0000-0002-9918-9493)
- Charlotte Perlowski
- Jodie A. Dionne
- Jorge E. Mejia-Galvis
- Kenneth H. Mayer (ORCID: https://orcid.org/0000-0001-8034-5110)
- Chunming Zhu
Institutions
- University of North Carolina at Chapel Hill (US)
- Louisiana State University (US)
- Family Health International 360 (US)
- National Institutes of Health (US)
- Johns Hopkins University (US)
- Emory University (US)
- University of Pittsburgh (US)
- University of Washington (US)
- University of Alabama at Birmingham (US)
- Magee-Womens Research Institute (US)
- Emmes (United States) (US)
- National Institute of Allergy and Infectious Diseases (US)
- Indiana University School of Medicine
- Fenway Health (US)
- Wake Forest University (US)
- Indiana University – Purdue University Indianapolis (US)
Publication Details
- Journal
- New England Journal of Medicine
- Published
- 2025-09-03
- DOI
- https://doi.org/10.1056/nejmoa2401802
- Citations
- 5
- Primary Topic
- Syphilis Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 5.82
Funders
- Emory University
- University of Washington
- Johns Hopkins University
- University of Pittsburgh
- National Institute of Allergy and Infectious Diseases