Monoclonal Antibodies in the Pathogenesis of Heparin-Induced Thrombocytopenia
The pathogenic antibodies in all nine patients with HIT were found to be monoclonal. This finding provides insight into the pathogenesis of HIT and has implications for improved diagnostics and targeted therapeutics. (Funded by the Canadian Institutes of Health Research and the National Institutes of Health.).
Authors
- Nikola Ivetic (ORCID: https://orcid.org/0000-0002-4463-254X)
- Rumi Clare (ORCID: https://orcid.org/0009-0009-5113-706X)
- Hossam A. Ali
- Igor A. Kaltashov (ORCID: https://orcid.org/0000-0002-4355-6039)
- John G. Kelton (ORCID: https://orcid.org/0000-0001-9418-2383)
- Daniil G. Ivanov (ORCID: https://orcid.org/0000-0003-2987-1048)
- Ishac Nazy (ORCID: https://orcid.org/0000-0002-5695-4343)
- Jared Treverton (ORCID: https://orcid.org/0009-0000-6416-2453)
- Yi Zhang (ORCID: https://orcid.org/0000-0001-9861-4681)
Institutions
- Amherst College (US)
- University of Massachusetts Amherst (US)
- McMaster University (CA)
Publication Details
- Journal
- New England Journal of Medicine
- Published
- 2025-09-03
- DOI
- https://doi.org/10.1056/nejmoa2507175
- Citations
- 6
- Primary Topic
- Heparin-Induced Thrombocytopenia and Thrombosis
- Type
- article
- Field-Weighted Citation Impact
- 12.04
Funders
- National Institutes of Health
- Canadian Institutes of Health Research