Residual Eosinophilic Inflammation of Sinonasal Mucosa Under the Maintenance Phase of Eosinophilic Granulomatosis With Polyangiitis

NPs with eosinophilic inflammation without blood eosinophilia can be observed during the maintenance phase of EGPA. Current treatments, including MPZ for EGPA and its comorbidities, may be insufficient to control comorbid CRS. Endotypic investigation of the sinonasal mucosa is required to elucidate its pathophysiology.

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Publication Details

Journal
Cureus
Published
2025-09-03
DOI
https://doi.org/10.7759/cureus.91556
Primary Topic
Sinusitis and nasal conditions
Type
article
Field-Weighted Citation Impact
0.00

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article

Residual Eosinophilic Inflammation of Sinonasal Mucosa Under the Maintenance Phase of Eosinophilic Granulomatosis With Polyangiitis

Goichi Kageyama, Kazuma Nishisaka, Shizuko Ainai, Masaaki Ishikawa et al.
2 links
Cureus
Sinusitis and nasal conditions
article

Residual Eosinophilic Inflammation of Sinonasal Mucosa Under the Maintenance Phase of Eosinophilic Granulomatosis With Polyangiitis

Goichi Kageyama, Kazuma Nishisaka, Shizuko Ainai, Masaaki Ishikawa, Mie Inoue
article en

Abstract

NPs with eosinophilic inflammation without blood eosinophilia can be observed during the maintenance phase of EGPA. Current treatments, including MPZ for EGPA and its comorbidities, may be insufficient to control comorbid CRS. Endotypic investigation of the sinonasal mucosa is required to elucidate its pathophysiology.

CureusVol. 17(9)
Hyogo Prefectural Amagasaki General Medical Center (JP), Kobe University (JP)
Japanese Society of Allergology, Ministry of Education, Culture, Sports, Science and Technology, Japan Society for the Promotion of Science
Openalex Percentile: Top 69%
Sinusitis and nasal conditions
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