Ureaplasma parvum impaired semen quality improves after doxycycline treatment in selected patients: a cohort study

The mere detection of Ureaplasma parvum does not appear to compromise semen quality and may not warrant routine antibiotic treatment. Nevertheless, in Ureaplasma parvum-positive patients with abnormal semen parameters and elevated inflammatory markers, targeted antibiotic therapy may improve sperm quality. These findings support a selective treatment strategy, emphasizing clinical context and inflammatory status rather than routine screening or treatment of all infected individuals.