Chronic stress synergizes with Listeria monocytogenes to promote intestinal adenomagenesis via myeloid-derived suppressor cells
Our results propose that chronic stress-induced gut barrier disruption may serve as a prerequisite for opportunistic pathogens to accelerate the development of precancerous lesions. Their synergistic effects reshape systemic/local immune responses, creating a microenvironment conducive to malignant transformation and tumor cell survival. These preliminary findings highlight potential clinical applications of psychological interventions and immune modulation strategies in preventing intestinal carcinogenesis.
Authors
- Lili Yin (ORCID: https://orcid.org/0000-0002-3649-1994)
- Ping Huang (ORCID: https://orcid.org/0000-0001-8685-6245)
- Ziqing Liu (ORCID: https://orcid.org/0000-0002-3821-5600)
- Yan-Juan Deng
- Rui He (ORCID: https://orcid.org/0000-0002-8314-9155)
- Siyuan Yang (ORCID: https://orcid.org/0000-0002-8087-7931)
- Mengmeng Wang (ORCID: https://orcid.org/0000-0002-6334-202X)
- Qiwen Yu
- Lv Zhou (ORCID: https://orcid.org/0000-0003-2571-0693)
- Ying Xiong (ORCID: https://orcid.org/0009-0009-8835-202X)
- Ran Wei (ORCID: https://orcid.org/0000-0001-9147-6327)
- Jinping Hu
- Huan Deng
- Pingqian Qi
- Suyi Xiong
Institutions
- Nanchang University (CN)
- First Affiliated Hospital of Jiangxi Medical College (CN)
- Second Affiliated Hospital of Nanchang University (CN)
- Third Affiliated Hospital of Nanchang University (CN)
- Beijing Hua Xin Hospital (CN)
- First Affiliated Hospital of Nanchang University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-09-03
- DOI
- https://doi.org/10.3389/fimmu.2025.1653548
- Citations
- 1
- Primary Topic
- Listeria monocytogenes in Food Safety
- Type
- article
- Field-Weighted Citation Impact
- 1.23
Funders
- National Science Foundation
- National Natural Science Foundation of China
- Education Department of Jiangxi Province