Comprehensive bioinformatics and in vivo validation reveal key molecular drivers of diabetic nephropathy progression
Our study identifies COL1A2, CD163, FN1, and CCL2 as key molecular signatures involved in the immunoinflammatory and fibrotic progression of diabetic nephropathy. These genes hold promise as potential biomarkers and therapeutic targets, offering novel insights into the molecular mechanisms and clinical management of DN.
Authors
- Xingyu He (ORCID: https://orcid.org/0000-0002-6620-6074)
- Shuo Wang (ORCID: https://orcid.org/0000-0002-1006-7175)
- Wei Liu (ORCID: https://orcid.org/0000-0001-8245-8645)
- Lin Mu (ORCID: https://orcid.org/0000-0003-2814-253X)
- Yakun Yang
Institutions
- Hebei Medical University (CN)
- Second Hospital of Hebei Medical University (CN)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2025-09-03
- DOI
- https://doi.org/10.3389/fendo.2025.1654401
- Citations
- 1
- Primary Topic
- Chronic Kidney Disease and Diabetes
- Type
- article
- Field-Weighted Citation Impact
- 1.43