Pharmacometrics modeling and simulation to assist phenobarbital dose optimization in dogs
The validated popPK model enables individualized PB dosing in dogs, accounting for variability in WT and age. This approach supports the implementation of MIPD in veterinary practice and may improve therapeutic outcomes while minimizing toxicity.
Authors
- Silvana Alvariza
- Gonzalo Suárez (ORCID: https://orcid.org/0000-0003-2452-3546)
- Manuel Ibarra (ORCID: https://orcid.org/0000-0002-0484-6367)
- Natalia Guevara (ORCID: https://orcid.org/0000-0002-5541-6316)
- Marta Vázquez (ORCID: https://orcid.org/0000-0002-8459-4859)
- Cecilia Maldonado (ORCID: https://orcid.org/0000-0002-9452-2111)
- Gimena Feijóo
Institutions
- Universidad de la República de Uruguay (UY)
- Universidad de Montevideo (UY)
Publication Details
- Journal
- Frontiers in Veterinary Science
- Published
- 2025-09-03
- DOI
- https://doi.org/10.3389/fvets.2025.1644003
- Primary Topic
- Pharmacological Effects and Toxicity Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00