IONPs combined with cytarabine downregulated IFITM3 expression to inhibit acute myeloid leukemia
IFITM3 knockdown in KG-1a cells inhibited proliferation and promoted apoptosis. The combination of IONPs and Ara-C may represent a promising therapeutic strategy for AML by suppressing IFITM3 expression, enhancing ROS levels, and inducing apoptosis. These findings suggest IFITM3 as a potential molecular target and highlight the synergistic efficacy of IONPs and Ara-C in AML treatment.
Authors
- Jun Dou (ORCID: https://orcid.org/0000-0001-6944-5874)
- Kena Liu
- Xueyang Bao
- Fengsu Zhao
- Hui Xu (ORCID: https://orcid.org/0000-0002-2888-1490)
- Mei Feng (ORCID: https://orcid.org/0009-0000-2326-4875)
- Rui Xue (ORCID: https://orcid.org/0000-0002-7150-9790)
Institutions
- Yunnan University (CN)
- Jiangsu Vocational College of Medicine (CN)
- Northern Jiangsu People's Hospital (CN)
- Second Affiliated Hospital of Nanjing Medical University (CN)
- Karamay Central Hospital of Xinjiang (CN)
- Dali University (CN)
- Southeast University (CN)
- Yangzhou University (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-09-03
- DOI
- https://doi.org/10.3389/fonc.2025.1515956
- Primary Topic
- Acute Myeloid Leukemia Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Southeast University
- National Key Research and Development Program of China