Structural valve deterioration is primarily caused by cyclic fatigue but not immune rejection
All BMVs had a significant extent of lipid deposition, hemorrhages, and tears, which eventually led to its mechanical incompetence. Strikingly, BMVs had less amount of immune cell infiltration as compared with BTVs. These results indicate that mechanical fatigue prevails over immune cell infiltration in driving the development of SVD.
Authors
- Tatiana N. Akentieva
- A. E. Kostyunin (ORCID: https://orcid.org/0000-0001-6099-0315)
- Т. В. Глушкова (ORCID: https://orcid.org/0000-0003-4890-0393)
- А. А. Хромов
- А. Н. Стасев (ORCID: https://orcid.org/0000-0003-1341-204X)
- K. Yu. Klyshnikov (ORCID: https://orcid.org/0000-0003-3211-1250)
- Е. А. Овчаренко (ORCID: https://orcid.org/0000-0001-7477-3979)
- Anton G. Kutikhin (ORCID: https://orcid.org/0000-0001-8679-4857)
- Vladislav A. Koshelev
- P.S. Onischenko
- Leo Bogdanov (ORCID: https://orcid.org/0000-0003-4124-2316)
Institutions
- Kuzbass Institute of Economics and Law (RU)
- Research Institute of Complex Problems of Cardiovascular Disease Russian Academy of Medical Sciences (RU)
- Kemerovo State University (RU)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-09-03
- DOI
- https://doi.org/10.3389/fimmu.2025.1652294
- Primary Topic
- Cardiac Valve Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Siberian Branch, Russian Academy of Sciences
- Russian Academy of Sciences