NADH supplementation improves human oocyte maturation and developmental competence of resulting embryos in controlled ovarian hyperstimulation cycles: a pilot study implicating the CDK2/GAS6 signaling pathway
This pilot study demonstrates that NADH, as a mitochondrial bioenergetic enhancer, ameliorates Human oocytes maturation and subsequent embryonic development, with this promotive effect appearing to be associated with upregulation of CDK2 and GAS6.
Authors
- Tingting Ye
- Hedong Lu
- Huijuan Zou (ORCID: https://orcid.org/0000-0001-8342-4711)
- Yongqi Fan
- Lu Xie (ORCID: https://orcid.org/0000-0003-2645-6439)
- Qiqi Zhang (ORCID: https://orcid.org/0009-0007-4456-216X)
- Dandan Yang (ORCID: https://orcid.org/0000-0002-7696-4434)
- K F Zhang
- Beili Chen (ORCID: https://orcid.org/0000-0002-1832-4615)
- Weiwei Zou (ORCID: https://orcid.org/0000-0002-5963-7247)
- Qiushuang Wang (ORCID: https://orcid.org/0000-0002-3975-3048)
- Ding Ding (ORCID: https://orcid.org/0000-0001-9850-9224)
- Zhiguo Zhang (ORCID: https://orcid.org/0000-0003-1483-3321)
- Chao Zhang (ORCID: https://orcid.org/0000-0002-0778-4608)
- Han Yang
- Min Xiong (ORCID: https://orcid.org/0009-0008-6083-0379)
Institutions
- Ministry of Education of the People's Republic of China (CN)
- Anhui University (CN)
- Anhui Medical University (CN)
- Anhui Academy of Medical Sciences (CN)
- Anhui Provincial Hospital (CN)
- First Affiliated Hospital of Anhui Medical University (CN)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2025-09-03
- DOI
- https://doi.org/10.3389/fendo.2025.1627679
- Primary Topic
- Reproductive Biology and Fertility
- Type
- article
- Field-Weighted Citation Impact
- 0.00