Zinc alleviates stroke development through autophagy-mediated modulation of immune microenvironment
Zinc confers neuroprotection in ischemic stroke by restoring autophagic flux and suppressing excessive innate inflammation through regulation of ZIARs. These findings underscore zinc's neuroprotective role via immune-autophagy crosstalk and position it as a potential strategy for stroke prevention and intervention.
Authors
- Aikebaier Yasen
- Alimujiang Abulaiti
- Jialong Chen (ORCID: https://orcid.org/0000-0002-5323-1801)
- Xin Liu (ORCID: https://orcid.org/0000-0002-7192-2788)
- Jiaxin He (ORCID: https://orcid.org/0000-0003-2333-2457)
- Zhengyang Lin (ORCID: https://orcid.org/0000-0002-9237-1380)
- Mulati Rexiati (ORCID: https://orcid.org/0000-0002-2415-9599)
- Jie Li (ORCID: https://orcid.org/0000-0003-3010-249X)
- Lifei Xing
- Zijie Qiu (ORCID: https://orcid.org/0000-0003-0728-1178)
- Dilihumaer Aili
- Xiaoqi Li (ORCID: https://orcid.org/0000-0002-4597-4226)
- Jiankun Luo
- Chaowen Huang (ORCID: https://orcid.org/0000-0001-9175-7073)
- Z. Qian (ORCID: https://orcid.org/0000-0002-7613-1168)
- Bing Meng
- Z. Y. You
- Hongming Yin
Institutions
- Guangdong Medical College (CN)
- Dongguan University of Technology (CN)
- Dongguan People’s Hospital (CN)
- Jiangmen Central Hospital (CN)
- Kashi University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-09-03
- DOI
- https://doi.org/10.3389/fimmu.2025.1666225
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Foundation for Innovative Research Groups of the National Natural Science Foundation of China
- Basic and Applied Basic Research Foundation of Guangdong Province