Single-cell transcriptomics reveals predominantly inflammatory endothelial cell responses and suppressed vascular repair in silicosis
These results indicate a pathological shift toward inflammation-amplifying endothelial cells and impaired reparative capacity during silicosis progression. Our findings provide new mechanistic insights into endothelial cell dysfunction in silicosis and highlight potential targets for therapeutic intervention.
Authors
- Heyang Li (ORCID: https://orcid.org/0000-0001-9794-5075)
- Dongli Cao
- Zequan Chen (ORCID: https://orcid.org/0009-0001-9002-7156)
- Jianhua Wang (ORCID: https://orcid.org/0000-0001-6831-9593)
- Bing Li (ORCID: https://orcid.org/0000-0001-7640-9468)
- Huashun Cui
Institutions
- University of Science and Technology of China (CN)
- Hefei University of Technology (CN)
- Anhui University of Science and Technology (CN)
- Fudan University Shanghai Cancer Center (CN)
- Huainan Normal University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-09-03
- DOI
- https://doi.org/10.3389/fimmu.2025.1629226
- Primary Topic
- Occupational and environmental lung diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00