Results of the international multicenter randomized, double-blind, placebo-controlled clinical trial for the evaluation of the efficacy and safety of the sequential therapy with ethylmethylhydroxypyridine succinate in patients in the acute and early
According to the clinical trial results, statistically significant differences were obtained, which confirm the greater efficacy of therapy using Mexidol compared to placebo in patients in the acute and early recovery periods of IS of moderate severity. This was observed in terms of reducing the degree of patients' disability and the severity of neurological symptoms, in terms of improving motor capabilities and increasing mobility. A similar safety profile was demonstrated for the long-term sequential therapy with Mexidol and Mexidol FORTE 250 and placebo.
Authors
- Н. В. Пизова (ORCID: https://orcid.org/0000-0002-7465-0677)
- Ella Iu. Solovyeva (ORCID: https://orcid.org/0000-0003-1256-2695)
- Е. В. Мельникова (ORCID: https://orcid.org/0000-0002-2076-4062)
- Е.С. Нургужаев
- Д. Р. Хасанова (ORCID: https://orcid.org/0000-0002-8825-2346)
- N. А. Shamalov (ORCID: https://orcid.org/0000-0001-6250-0762)
- В В Машин (ORCID: https://orcid.org/0000-0003-0085-3727)
- И Е Повереннова (ORCID: https://orcid.org/0000-0002-2594-461X)
- Lyudmila V. Roshkovskaya
- A. S. Agafina (ORCID: https://orcid.org/0000-0003-2598-4440)
- Fedin Ai (ORCID: https://orcid.org/0000-0002-6996-2828)
- Svetlana E Chuprina (ORCID: https://orcid.org/0009-0004-5302-0061)
- S. N. Yanishevsky
- G. Rakhimbaeva (ORCID: https://orcid.org/0000-0002-5547-7610)
Institutions
- Kazan State Medical University (RU)
- Ulyanovsk State University (RU)
- Yaroslavl State Medical Academy (RU)
- Alexandrovska Hospital (BG)
- Federal Almazov North-West Medical Research Centre (RU)
- Pirogov Russian National Research Medical University (RU)
- Leningrad Regional Cancer Center (RU)
- City Hospital No. 40 (RU)
- Samara Regional Clinical Hospital named after V.D. Seredavina (RU)
- Tashkent Medical Academy (UZ)
- Federal Center of Brain Research and Neurotechnologies
Publication Details
- Journal
- S S Korsakov Journal of Neurology and Psychiatry
- Published
- 2025-09-03
- DOI
- https://doi.org/10.17116/jnevro202512508240
- Citations
- 1
- Primary Topic
- Neurological Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.84