The Causal Relationship Between Circulating Inflammatory Proteins and Tinnitus: A Mendelian Randomization Study Mediated by Blood Metabolites

This first MR-based evidence establishes CCL19-pantothenate axis dysfunction as a causal driver of tinnitus, prioritizing these biomarkers for early detection. It also revealed the pivotal role of circulating inflammatory proteins and metabolic dysregulation in the pathogenesis of tinnitus. The findings provide new evidence-based medical support for specific circulating inflammatory proteins and metabolites as biomarkers for early tinnitus prediction and risk assessment. They also offer valuable insights for subsequent research on tinnitus pathophysiological mechanisms and precision medicine applications.