ZDHHC5 Mediates Immune Dysregulation Driving Generalized Anxiety Disorder Risk
The findings indicate that ZDHHC5 contributes to the pathogenesis of GAD by modulating SSC-A on CD4+ T cells, thereby offering novel targets for the investigation of GAD pathophysiology.
Authors
- Gengchen Lu
- Ruimin Ma (ORCID: https://orcid.org/0000-0002-6051-8093)
- Nianqin Li (ORCID: https://orcid.org/0000-0002-5407-4668)
- Bin Cheng (ORCID: https://orcid.org/0000-0003-1568-8760)
- Shimin Zong (ORCID: https://orcid.org/0009-0004-3709-1599)
- Sun Fuqiang (ORCID: https://orcid.org/0009-0004-0096-064X)
- Yifei Feng (ORCID: https://orcid.org/0000-0002-5222-7106)
- Kun Dai
- Zhe Ren (ORCID: https://orcid.org/0009-0008-6170-9757)
Institutions
- Shandong University of Traditional Chinese Medicine (CN)
- Affiliated Hospital of Shandong University of Traditional Chinese Medicine (CN)
- Xiamen Tobacco Industry (China) (CN)
Publication Details
- Journal
- Brain and Behavior
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1002/brb3.70818
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00