SPARC aberrant methylation in idiopathic pulmonary fibrosis: an explorative study
Our explorative study suggests that promoter methylation of the <i>SPARC</i> gene is linked to IPF but not to NIPF, and could represent a potential molecular marker of disease, thus warranting further investigations on larger cohorts.
Authors
- Flavia Centra (ORCID: https://orcid.org/0000-0003-1945-6975)
- Elisa Gili (ORCID: https://orcid.org/0000-0002-1885-5387)
- Paola Parente (ORCID: https://orcid.org/0000-0003-0591-6723)
- Antônio Rossi (ORCID: https://orcid.org/0000-0003-3295-0345)
- Marco Donatello Delcuratolo (ORCID: https://orcid.org/0000-0003-3151-9166)
- Lucia Anna Muscarella (ORCID: https://orcid.org/0000-0002-1866-8151)
- Paolo Graziano (ORCID: https://orcid.org/0000-0001-7066-7896)
- Angelo Sparaneo (ORCID: https://orcid.org/0000-0002-3211-3072)
- Giulio Rossi (ORCID: https://orcid.org/0000-0001-8855-1218)
- Federico Pio Fabrizio (ORCID: https://orcid.org/0000-0002-9122-1348)
- Massimiliano Copetti (ORCID: https://orcid.org/0000-0002-7960-5947)
- Francesco Delli Muti
Institutions
- Università degli Studi di Enna Kore (IT)
- Casa Sollievo della Sofferenza (IT)
- University of Catania (IT)
- Fondazione Poliambulanza Istituto Ospedaliero (IT)
Publication Details
- Journal
- Frontiers in Cell and Developmental Biology
- Published
- 2025-09-03
- DOI
- https://doi.org/10.3389/fcell.2025.1639844
- Primary Topic
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00