Oleanolic acid alleviates ovarian cancer by regulating the miR-122/PDK4 axis to induce autophagy and inhibit glycolysis in vivo and in vitro
In conclusion, OA induced autophagy and inhibited glycolysis to attenuate OC progression by regulating the miR-122/PDK4 axis, providing a theoretical basis for clinical treatment of OC with OA, and novel therapeutic targets of OC.
Authors
- Ningwei Zhao (ORCID: https://orcid.org/0000-0002-7637-2893)
- Min Lin (ORCID: https://orcid.org/0000-0002-8992-6621)
- Jing Yu (ORCID: https://orcid.org/0000-0002-6371-3724)
- Zhen Zeng
- Qing Lin (ORCID: https://orcid.org/0000-0001-5150-6552)
Institutions
- Fujian Medical University (CN)
- Marine Design & Research Institute of China (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-09-03
- DOI
- https://doi.org/10.3389/fonc.2025.1670758
- Citations
- 1
- Primary Topic
- Natural product bioactivities and synthesis
- Type
- article
- Field-Weighted Citation Impact
- 0.81