Long-term gabapentin treatment impairs cognitive function in aged mice via tau hyperphosphorylation
Long-term GBP treatment is detrimental to cognitive function in aged mice. GBP suppressed Sirt1 expression, leading to elevated CaMKIIα level and hyperphosphorylation of tau, and boosting Sirt1 activity curbed the adverse effect of GBP on memory in aged mice.
Authors
- Zhongcong Xie (ORCID: https://orcid.org/0000-0002-0720-1759)
- Yuanlin Dong (ORCID: https://orcid.org/0000-0002-4760-0519)
- Min Yan (ORCID: https://orcid.org/0000-0002-1355-1261)
- Jinsheng Yang (ORCID: https://orcid.org/0000-0002-1054-6344)
- Jiajia Dai (ORCID: https://orcid.org/0009-0004-6678-9531)
- Lucy Chen (ORCID: https://orcid.org/0000-0002-9956-8194)
- Suyun Xia (ORCID: https://orcid.org/0000-0002-0395-5748)
- Jianren Mao (ORCID: https://orcid.org/0000-0003-0298-486X)
- Shiqian Shen (ORCID: https://orcid.org/0000-0003-0062-6831)
- Na Li (ORCID: https://orcid.org/0000-0002-9383-3049)
- Xinbo Wu (ORCID: https://orcid.org/0000-0002-9846-2857)
- Zerong You
- Shiyu Wang (ORCID: https://orcid.org/0009-0007-5888-4119)
Institutions
- Shriners Hospitals for Children - Erie (US)
- Shriners Hospitals for Children - Boston (US)
- Shanghai Tenth People's Hospital (CN)
- Center for Pain and the Brain (US)
- Second Affiliated Hospital of Zhejiang University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-09-03
- DOI
- https://doi.org/10.3389/fphar.2025.1616775
- Citations
- 1
- Primary Topic
- Pain Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.16
Funders
- National Institutes of Health