γ-Oryzanol-Loaded PLGA nanoparticles: enhanced drug delivery and therapeutic efficacy for breast cancer therapy
Collectively, these findings demonstrate that γ-oryzanol@PLGA NPs significantly improve drug delivery efficiency and therapeutic potency while maintaining excellent biocompatibility. This presents a promising nanoplatform for breast cancer treatment, warranting further preclinical development. Future studies should focus on <i>in vivo</i> validation and the exploration of combination therapies to fully realize the potential of this novel approach.
Authors
- Ze Qiang Zhao
- Huazhong Li (ORCID: https://orcid.org/0000-0003-4506-609X)
- Nannan Cui
- Chuanliang Zhao (ORCID: https://orcid.org/0000-0003-2907-0507)
- Xiaodan Zhu (ORCID: https://orcid.org/0000-0001-7080-1741)
- Weiwei Shi (ORCID: https://orcid.org/0009-0002-8282-7193)
- Qingbin Ni (ORCID: https://orcid.org/0000-0001-7732-8627)
- Xue-Song Wu (ORCID: https://orcid.org/0000-0001-5044-5719)
- Chunli Yu
- Xiaokun Geng (ORCID: https://orcid.org/0000-0001-8918-8748)
- Pengcheng Xia (ORCID: https://orcid.org/0000-0001-8524-7421)
- Teng Ma (ORCID: https://orcid.org/0000-0002-4144-2118)
Institutions
- Taian City Central Hospital (CN)
- Shandong Maternal and Child Health Hospital (CN)
- Shandong Agricultural University (CN)
Publication Details
- Journal
- Frontiers in Bioengineering and Biotechnology
- Published
- 2025-09-03
- DOI
- https://doi.org/10.3389/fbioe.2025.1675338
- Citations
- 1
- Primary Topic
- Nanoparticle-Based Drug Delivery
- Type
- article
- Field-Weighted Citation Impact
- 0.60
Funders
- China Postdoctoral Science Foundation
- Qingdao University