Mechanism of IFITM1 regulating epidural scar hyperplasia after laminectomy through SMAD3/CBR4 pathway
These findings demonstrate that IFITM1 inhibits fibroblast proliferation and differentiation <i>via</i> SMAD3 signaling suppression and modulates adipocyte fibrosis by regulating CBR4 expression, thereby influencing epidural scar hyperplasia post-laminectomy.
Authors
- Jun Liu (ORCID: https://orcid.org/0000-0003-3756-3627)
- Haoran Wang (ORCID: https://orcid.org/0000-0002-3626-2286)
- Zekai Zhu
Institutions
- Tongji University (CN)
- Second Affiliated Hospital of Nanjing Medical University (CN)
- Tongji Hospital (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-09-03
- DOI
- https://doi.org/10.3389/fimmu.2025.1628970
- Primary Topic
- Spine and Intervertebral Disc Pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00