Endotheliopathy syndromes, TA-TMA, and SOS, are risk factors for morbidity and mortality in critically ill pediatric hematopoietic cell transplant recipients
In this contemporary cohort with a high prevalence of infection, the NRM of critically ill allogeneic HCT recipients was lower than the historic rates, and 62.5% of children requiring IMV were successfully extubated. SOS and TA-TMA were risk factors for highly morbid ICU complications and death despite early intervention. Alternative approaches to these diseases and their drivers and initiation of early RRT may avert death.
Authors
- Elizabeth Stenger (ORCID: https://orcid.org/0000-0002-1386-6685)
- Erin Frost
- Muna Qayed (ORCID: https://orcid.org/0000-0001-7689-343X)
- Katie Liu (ORCID: https://orcid.org/0000-0002-5687-8969)
- Kirsten M. Williams (ORCID: https://orcid.org/0000-0001-9372-5286)
- Michelle Long Schoettler (ORCID: https://orcid.org/0000-0003-4565-6399)
- Adrianna Westbrook (ORCID: https://orcid.org/0000-0001-9309-6205)
- Zhulin He (ORCID: https://orcid.org/0000-0002-5852-8065)
- Taylor Fitch (ORCID: https://orcid.org/0000-0002-5128-9268)
- Pradip Kamat (ORCID: https://orcid.org/0000-0002-9633-0973)
- Keiko M. Tarquinio (ORCID: https://orcid.org/0000-0003-2688-1021)
- Shivani Goel (ORCID: https://orcid.org/0000-0001-7099-5400)
Institutions
- Children's Healthcare of Atlanta (US)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-09-03
- DOI
- https://doi.org/10.3389/fonc.2025.1642939
- Primary Topic
- Hematopoietic Stem Cell Transplantation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- American Society of Hematology