CD3zeta-mediated modulation of TCR signaling: a novel strategy for neuroprotection in retinal ganglion cell degeneration
This study demonstrates that CD3ζ plays a critical role in immune-mediated neurodegeneration in glaucoma. CD3ζ knockdown promotes RGC survival by modulating MAPK and NF-κB signaling pathways and regulating apoptosis and inflammation. These findings underscore the therapeutic potential of targeting TCR signaling to complement existing IOP-lowering treatments, offering a novel approach to preserving visual function in glaucoma.
Authors
- Wenye Cao (ORCID: https://orcid.org/0000-0003-1781-0555)
- Kexin Xu
- Zhiyi Wang (ORCID: https://orcid.org/0000-0002-9349-4059)
- Ning Yang (ORCID: https://orcid.org/0000-0003-3036-0202)
- Yiqiao Xing (ORCID: https://orcid.org/0000-0003-4482-3319)
- Lu Yu (ORCID: https://orcid.org/0009-0007-9449-8274)
- Ningzhi Zhang (ORCID: https://orcid.org/0000-0002-9570-4726)
Institutions
- Wuhan University (CN)
- Renmin Hospital of Wuhan University (CN)
Publication Details
- Journal
- Frontiers in Cell and Developmental Biology
- Published
- 2025-09-03
- DOI
- https://doi.org/10.3389/fcell.2025.1652041
- Citations
- 2
- Primary Topic
- Glaucoma and retinal disorders
- Type
- article
- Field-Weighted Citation Impact
- 3.41