Physicochemical and biological characterization of a bispecific antibody in a CrossMab/KIH format that targets EGFR and VEGF-A
Based on the combinatorial mechanism of action and our characterization findings, we concluded that two or more bioassays may be needed to accurately assess the activity of both arms of this type of BsAb.
Authors
- Shraboni Dutta (ORCID: https://orcid.org/0000-0002-8000-8111)
- Wen Jin Wu (ORCID: https://orcid.org/0000-0001-5063-0957)
- Safiat Ayinde
- Nishant Mohan
Institutions
- Center for Drug Evaluation and Research (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-09-03
- DOI
- https://doi.org/10.3389/fimmu.2025.1659966
- Primary Topic
- Monoclonal and Polyclonal Antibodies Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Department of Energy
- U.S. Food and Drug Administration
- Oak Ridge Institute for Science and Education
- Office of Women's Health