Severity-dependent IgG epitope profiling in COVID-19 reveals differential recognition of pathogen-derived antigens
SARS-CoV-2 infection reshapes the IgG epitope repertoire in a severity-dependent manner, extending to antigens from unrelated pathogens. This phenomenon may reflect underlying immune dysregulation or idiotype-driven interactions. Comprehensive profiling of pathogen-related IgG responses may reveal potential biomarkers of disease severity. This phenomenon may inform future investigations aimed at improving personalized management strategies for co-infected or immunocompromised patients.
Authors
- Jefferson Russo Victor (ORCID: https://orcid.org/0000-0001-6092-8394)
- Juliana Pereira Borges (ORCID: https://orcid.org/0000-0002-3581-7251)
- André Luís Lacerda Bachi (ORCID: https://orcid.org/0000-0001-8266-1416)
- Beatriz Oliveira Fagundes (ORCID: https://orcid.org/0000-0001-9628-9184)
- Isabella Siuffi Bergamasco
- Maria Notomi Sato (ORCID: https://orcid.org/0000-0002-7911-1824)
- N Machado (ORCID: https://orcid.org/0009-0003-5983-312X)
- Fábio da Ressureição Sgnotto
- Lais Alves do Nascimento
Institutions
- Universidade de São Paulo (BR)
- Universidade de Santo Amaro (BR)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-09-03
- DOI
- https://doi.org/10.3389/fimmu.2025.1668223
- Citations
- 2
- Primary Topic
- SARS-CoV-2 and COVID-19 Research
- Type
- article
- Field-Weighted Citation Impact
- 2.79
Funders
- Fundação de Amparo à Pesquisa do Estado de São Paulo
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Universidade de São Paulo