Systemic inflammation mediates the association between the dietary index for gut microbiota and serum Klotho: evidence from NHANES 2007–2016

A higher DI-GM Score is significantly associated with increased serum Klotho levels among middle-aged and older adults, with systemic inflammation serving as a partial mediator. These findings suggest that dietary patterns promoting gut microbiota health may enhance Klotho levels, potentially contributing to anti-inflammatory and anti-aging processes in this population.